The development of inhibitory antibodies to therapeutic factor VIII (FVIII) in up to 40% of people with severe hemophilia A (HA) is the major complication in treatment/prevention of hemorrhages. The reasons some people with HA develop inhibitors while others do not, remain unclear.
In this session from the WFH 2020 Virtual Summit, Sebastien Lacroix-Desmazes, Kathleen Pratt and Valder Arruder summarize our understanding of anti-FVIII immune responses, the roles of T cells, both effector and regulatory, and generally discuss the interplay between FVIII and the immune system, both in the case of replacement therapy and in gene therapy.
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Also Available In: English, Spanish This is not an official WFH translation. This resource has been translated with permission by
In the Monday morning session entitled Inhibitors: Clinical Aspects, Jan Astermark described the different diagnostic assays laboratories can carry out