WFH NETWORK

Inhibitors – Think differently | Virtual Summit 2020

 
Details

Year: 2020

Language: English

Author(s): World Federation of Hemophilia

Date: June 15, 2020

Also Available In: Spanish

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Additional Information

The development of inhibitory antibodies to therapeutic factor VIII (FVIII) in up to 40% of people with severe hemophilia A (HA) is the major complication in treatment/prevention of hemorrhages. The reasons some people with HA develop inhibitors while others do not, remain unclear.

In this session from the WFH 2020 Virtual Summit, Sebastien Lacroix-Desmazes, Kathleen Pratt and Valder Arruder summarize our understanding of anti-FVIII immune responses, the roles of T cells, both effector and regulatory, and generally discuss the interplay between FVIII and the immune system, both in the case of replacement therapy and in gene therapy.

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The WFH does not engage in the practice of medicine and under no circumstances recommends particular treatment for specific individuals. For diagnosis or consultation on a specific medical problem, the WFH recommends that you contact your physician or local treatment centre. Before administering any products, the WFH urges patients to check dosages with a physician or hemophilia centre staff, and to consult the pharmaceutical company’s printed instructions.

The WFH does not promote any particular pharmaceutical product and any mention of any commercial brand in this presentation is strictly for educational purposes.