Molecular Diagnosis of von Willebrand Disease

The accurate diagnosis of von Willebrand disease (VWD) is crucial to its management. This resource describes the techniques used to determine the genetic nature, or genotype, of a suspected case of VWD. The companion monograph, TOH 55 Diagnosis of von Willebrand Disease: Phenotypic Characterization, provides a detailed review of the laboratory tests that can be […]

WFH Webinar: Treatment Options for Hemophilia in the Developing World

On December 16, 2016, the WFH in collaboration with the ISTH, recorded a live interactive webinar on the challenges and opportunities of treatment options for hemophilia in the developing world, now available for viewing here. Introduced by Marijke van den Berg, Rolf Ljung opened with a summary of the lessons learned from decades of experience […]

Factor VIII Inhibitor Assay – Lab Manual Video

This step-by-step video clearly demonstrates the correct technique for the execution of the manual assay for the presence FVIII inhibitors. Supplementing the Lab Manual written protocol (Section 28), it also explains the theory behind the assay, details the important reagents, discusses the challenges posed by limited resources, and works through the plotting and interpretation of […]

One-Stage Assay of Factor VIII (FVIII) – Lab Manual Video

This step-by-step video clearly demonstrates the correct technique for the execution of the most commonly used manual technique in the diagnosis of bleeding disorders: the one-stage assay for FVIII. Supplementing the Lab Manual written protocol (Section 23), it also explains the theory behind the assay, details the important reagents, discusses the challenges posed by limited […]

APTT – Lab Manual Video

This step-by-step video clearly demonstrates the correct technique for the execution of the fundamental manual technique that constitutes the basis for the most commonly used assays in the diagnosis of bleeding disorders: the activated partial thromboplastin time (APTT). Supplementing the Lab Manual written protocol (Section 13), it also explains the theory behind the assay, details […]