The development of inhibitory antibodies to therapeutic factor VIII (FVIII) in up to 40% of people with severe hemophilia A (HA) is the major complication in treatment/prevention of hemorrhages. The reasons some people with HA develop inhibitors while others do not, remain unclear.

In this session from the WFH 2020 Virtual Summit, Sebastien Lacroix-Desmazes, Kathleen Pratt and Valder Arruder summarize our understanding of anti-FVIII immune responses, the roles of T cells, both effector and regulatory, and generally discuss the interplay between FVIII and the immune system, both in the case of replacement therapy and in gene therapy.

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This WFH webinar was originally presented in English.